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Respiratory and associated atopy outcomes, at primary school age, in preterm infants born at < 30 weeks gestation and/or < 1000 gms with chronic lung disease

Presented at the Neonatal Society 2012 Summer Meeting (programme).

Astle V1, Charles B2, Broom M2, Ringland C2, Ciszek K3, Kljakovic M3, Todd DA2,3

1 Nottingham Medical School, Nottingham, England
2 Centre for Newborn Care (CNC), Canberra Hospital, Australia
3 ANU Medical School, Canberra, Australia

Background: Pulmonary function abnormalities and hospital re-admissions in survivors of neonatal lung disease remain highly prevalent. The aim is to investigate the respiratory and associated atopy outcomes in preterm infants < 30 weeks gestational age (GA) and/or birth-weight (Bwt) <1000 gms.

Methods: All surviving preterm infants fulfilling the above criteria admitted to the CNC from Jan 1st 2001 to 31st Dec 2003 were enrolled. Parents received a questionnaire regarding respiratory/atopy symptoms, use of respiratory medications, medical follow up. The group was divided into those with or without chronic lung disease (CLD-oxygen at 36 weeks post-conceptional age) for analysis.

Results: Parents of 93 eligible children received questionnaires with a 57% return rate (53/93). 28 preterm infants had CLD and 25 no CLD. GA and Bwt were significantly different between the groups (26.91.6 and 973246 vs. 28.60.9 and 1221208 (p=0.000 and p=0.000) respectively). Despite the lower GA and Bwt, having CLD did not predispose children to asthma or atopic diseases. There was no significance found when comparing GA and birth weight for those who had asthma and those that did not (Asthma vs. no asthma: Mean GA= 27.5 Wks vs. 27.8 Wks (p=0.476), Mean Bwt= 999.7g vs. 1125.7g (p=0.112). The questionnaire showed that the infants with CLD were significantly more likely to have a paediatrician [p=0.011].

Conclusion: We could not demonstrate respiratory and/or atopy differences between the CLD and the non-CLD groups.

Corresponding author:

1. Vrijlandt EJ, Boeson HM, Gerritsen J, Stremmelaar EF Duiverman EJ: Respiratory health in prematurely born preschool children with and without bronchopulmonary dysplasia. J Pediatr 2007;150:256-61
2. Todd DA, Jana A, John E. Chronic oxygen dependency in infants at 24 to 32 weeks gestation: The role of antenatal and neonatal factors. J. Paediatr. Child Health. 1997; 33: 402-407.
3. Glasgow NJ, Ponsonby AL, Yates RE, McDonald T, Attewell R. Asthma screening as part of a routine school health assessment in the Australian Capital Territory. Med J Aust. 2001 Apr 16;174(8):384-8.

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